ReadCube, the reference manager software from Nature Publishing Group, has recently released major update/re-development, which finally makes it a usable gadget and a legitimate competitor of Mendeley, my favorite one in this category. Since my early days in science (2008 ish), I’ve always wanted a […]
Category: SCIENCE
chemogenomics
I was about to write something about this study led by Guri Giaever’s group from my beloved U of T MoGen department, when I saw the update from Derek Lowe’s blog on the same subject, where he and a few fellow chemists have spotted some silly chemistry mistakes. First, they […]
Cysteine and Huntington’s disease: a very ambiguous link
This paper is interesting. It’s not substantial. I take it as a grain of salt. No, I don’t like it at all. They were seeing reduced level of an metabolic enzyme Cystathionine γ-lyase (CSE), which makes cysteine and hydrogen sulfide in three models of huntington’ […]
yet another megabase long enhancer
I like this paper a lot because it’s yet another good example of decoding the functions of non-coding disease variants, and what’s more, it’s a megabase-long looping enhancer! I’ll never forget, from my college biology class, that crazy drawing of how enhancer elements might work: a […]
PAMPs, tyrosine kinases and plant immunity
这篇文章单纯的让我想起了08年我做的第一份研究。 同样的Arabidopsis thaliana, 同样的Pseudomonas syringae, 同样的host-pathogen interaction, 同样的PAMPs。我的工作那么简单，和这篇文章一样简单，直接。 可科研再也没有那么纯粹过；人也是。 那时候每天像白开水一样的过，每天刷试管，洗盘子；看着种子一点点从土里长出绿叶，在温室听广播里泡沫一样的流行音乐边收集种子。下了工时而去水泥球场打球，有时去吃立着的铁盘里盛的披萨。那时候我不认识很多人。那时候我认识很多人。 那时候我喜欢被太阳晒的发痒的皮肤，喜欢楼道水泉里喷出的冰凉到大脑空白的水，喜欢硬的吱嘎吱嘎的单人床，喜欢图书馆高吊的洁白的灯。 那时候我爱音乐； 那时候我爱孤独； 那时候我爱女孩； 那时候我爱忧伤； 是什么改变了我们，我们又改变了什么。 那时的我拒绝改变，拒绝妥协； 那时的我拒绝世俗，拒绝道德； 那时的我拒绝软弱，拒绝将就； 那时的我无情，拒绝了自我。 是什么改变了我们，我们又改变了什么。 那时的我不曾后悔。
